Once Marina distinguished herself in theatre, she began to expand her acting career into television. She appeared in several popular British television series such as Minder & Hazel and starred in the critically acclaimed made for British television film One Last Chance. Marina also appeared in feature films produced on both sides of the Atlantic including: The Wicked Lady with Faye Dunaway; Death Wish III opposite Charles Bronson; Blind Date with Bruce Willis and Richard Donner's The Thief of Baghdad.

But it was Marina's riveting portrayal of Deana Troi, the psychic counselor, for seven years on the television series Star Trek: The Next Generation, as well as her co-starring role with Patrick Stewart in the feature films Star Trek: Generations, Star Trek: First Contact and in the most recently released, Star Trek: Insurrection that has brought her legions of fans throughout the galaxy.

Ms. Sirtis made her American theatre debut in Hartford Stage's production of Loot and then starred in the world premiere of Neil Simon's Hotel Suite at the Walnut Street Theatre in Philadelphia, both of which won her exceptional praise for her performances.